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The 3D-Bioplotter® Family
Education/Research Medical/Biofabrication

The 3D-Bioplotter® has the capacity of fabricating scafolds using the widest range of materials of any singular Rapid Prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals.


A recognized world leader in biofabrication, EnvisionTEC's 3D-Bioplotter family is being used for groundbreaking medical research and manufacturing. Launched in 2000, the 3D-Bioplotter is the most seasoned bioprinter in the market, backed by the most research, more than 150 research papers to date.

Most research done to date using these machines has been in the pre-clinical setting, yielding many publications by pre-eminent scientists from the materials science, neuroimaging, and toxicology disciplines. In the clinical setting, patient CT or MRI scans are used to create STL files to print solid 3D models which can then be used as templates for implants.

Tissue Engineering and Controlled Drug Release require 3D scafolds with well-defined external and internal structures. The 3D-Bioplotter® has the capacity of fabricating scafolds using the widest range of materials of any singular Rapid Prototyping machine, from soft hydrogels over polymer melts up to hard ceramics and metals. Complex inner patterns can easily be designed using the 3D-Bioplotter® software to both control the mechanical properties, increase cell adhesion, as well as improve the flow of nutrient media throughout the interconnecting pores of the printed implants.

With three levels of functionality — Starter, Developer and Manufacturer — this family of bioprinters, as shown below, processes open-source biomaterials using air or mechanical pressure to a syringe, which can fabricate scaffolds to create tissue, organs and more. Our bioprinters are extremely accurate with X-Y repeatability down to 1 μm. All models have been designed for use in a sterile biosafety cabinet, meet standards for clinical trials and offer build sizes up to 3152.87 cubic centimeters.

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A simple process

A liquid, melt, paste or gel is dispensed from a material cartridge through a needle tip from a 3-axis system to create a 3D object.

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One single requirement

The material to be used must, through a physical or chemical reaction, solidify.

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A world of possibilities

The widest range of materials of any 3D printing technology can be processed.


3D Bioplotter Manufacturer Series

Manufacturer Series
Education/Research Medical/Biofabrication

The 3D-Bioplotter System is a versatile rapid prototyping tool for processing a great variety of biomaterials for computer-aided tissue engineering (CATE), from 3D CAD models and patient CT data to the physical 3D scaffold with a designed and defined outer form and an open inner structure.

The Manufacturer Series is the most full featured of the Bioplotter family affording greater flexibility and enhanced usability.

  • Built-in camera to enhance needle calibration and to ensure consistent prints.
  • Temperature controlled build platform and sensor ports. This allows greater material variety and finely tuned environments for low tolerance scaffolding.
  • Five cartridges slots for more materials in a single print.


3D Bioplotter Developer Series

Developer Series
Education/Research Medical/Biofabrication

The 3D-Bioplotter Developer Series is designed for research groups new to the field of tissue engineering, as well as for specialized use, where limited capability may still meet requirements. It consists of the same basic hardware and software as the Manufacturer Series with reduced functionality regarding camera and park positions, but is still capable of using a UV curing head and an optional heated platform.


3D Bioplotter Starter Series

Starter Series
Education/Research Medical/Biofabrication

  • Designed for research groups new to the field of tissue engineering with few requirements in parallel material processing and automation.
  • Consisting of the same basic hardware and software as the Manufacturer & Developer Series, but lacking modular capability and platform temperature control.
  • Not upgradable to the same capability of the Developer or Manufacturer Series.



Key Features

A new user management allows users to both share projects, materials and patterns, as well as have their own separate set of files for improved overview and security.

Input of outer shapes through STL files.

Multi-part and multi-material capable through the use of an automatic tool changer and multiple print heads.

Generation of volume support structures for complex shapes.

Database of inner patterns (user-editable) in the controlling software, avoiding requiring patterns in the STL files.

Complex inner pattern with straight lines, zig-zag shapes and wave forms as well as hexagon shapes, including shift functions for “in between the lines”printing.

Database of materials (user-editable) with all process parameters.

Material life time control to avoid scaffold fabrication with degraded materials.

Individual temperature control of each printing head, both in the parking positions, as well as during printing.

Temperature curves with up to 5 set points and waiting times.

Complete control of all printing parameters (temperature, pressure, speed, etc) through the software.

Improved surface finish of fabricated parts using randomized start position in outer contours.

2D Dot-Printing (Biopatterning) capability.

Low Temperature Print Head (0 °C to 70 °C) with disposable PE cartridges.

High Temperature Print Head (30 °C to 250 °C) with reusable stainless steel cartridges.

UV Curing Head (365 nm).

Needle cleaning station, with automatic cleaning before and during the print project available.

Luer Lock needle tips, 0.1mm to 1.0mm inner diameter available.

LOG file creation after project completion with all relevant data.

Footprint (L x W x H): 976 x 623 x 773 mm
Weight: About 130 kg
Electrical Requirements: 100-240 V AC, 50/60 Hz
Compressed Air Requirements: 6 - 10 bar (85 - 145 psi)

Automatic Platform Height Control for Petri Dishes, Well Plates, as well as other printing surfaces.

Manufacturer & Developer Series only

Automatic recalibration of park position coordinates in extensively used 3D-Bioplotters.

Manufacturer & Developer Series only

Photographic log of the full platform for each layer available for verification of error-free object interior after printing.

Manufacturer Series only

Mid-print measurement of strand dimensions using the built-in camera.

Manufacturer Series only

Comparison Table

Starter Series Developer Series Manufacturer Series
Primary Market Medical/Biofabrication
Medical/Biofabrication
Medical/Biofabrication
Medical/Biofabrication
Medical/Biofabrication
Medical/Biofabrication
Filters Included Particle Sterile and Particle Sterile and Particle
Platform Temperature Control No Yes (Chiller not included): -10° – 80°C Yes (Chiller Included): -10° – 80$°C
Max Heads 2 3 5
Head Temperature Range High: 30° – 250°C Low: 0° – 70°C
High: 30° – 250°C
Low: 0° – 70°C
High: 30° – 250°C
No. of Heads Included 2 2 2
Tool Changer Type Fixed Side-By-Side Tools Modular Tool Changer Modular Tool Changer
Cartridge Sizes 3-30 ml 10 – 30 ml 10 – 30 ml
Other Usable Modules None All All
Platform Height Control Manual Automatic Automatic
Needle Calibration Photo Sensor Photo Sensor Camera
Material Calibration Manual Manual Semi-automatic
External Temp. Ports 0 0 4
Included PC Built-in PC Professional PC Professional PC
Build Volume (XYZ) 150 x 150 x 140 mm 150 x 150 x 150 mm 150 x 150 x 150 mm
Speed 0.1 – 150 mm/s 0.1 – 150 mm/s 0.1 – 150 mm/s
Minimum Strand Diameter 0.100 mm - Material Dependent 0.100 mm - Material Dependent 0.100 mm - Material Dependent
Axis Resolution (XYZ) 0.001 mm 0.001 mm 0.001 mm

Videos

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